Diastolic dysfunction of the left ventricle in HIV-infected patients, clinical and prognostic relationships
https://doi.org/10.33667/2782-4101-2024-1-10-16
Abstract
Diastolic dysfunction in HIV-infected patients is a common problem, the pathway of which is based on chronic low-intensity inflammation, and whose consequences are associated with progression of chronic heart failure (CHF) and death.
The aim of the study was to evaluate clinical, echocardiographic and laboratory data of patients with diastolic left ventricular myocardial dysfunction infected with HIV and to present new prognostic relationships.
Within the framework of a one-stage, screening, clinical study in the conditions of a multidisciplinary clinic, 240 patients with HIV infection were examined, and 136 of them showed signs of diastolic dysfunction. The development of diastolic dysfunction in HIV-infected patients is a factor provoking the development and progression of CVD, ventricular rhythm disturbances, ischemic heart disease, and anemia. Diastolic dysfunction in HIV-infected patients increases the risks of death within 2 years by 1.46 times. Increase of NT-proBNP concentration in plasma of HIV-infected patients ≥ 185.7 pg/mL is associated with the development of diastolic dysfunction in them.
About the Author
O. G. Goryacheva
Perm State Medical University named academician E.A. Wagner
Russian Federation
Russian Federation
Olga Georgievna Goryacheva, candidate of medical sciences, associate professor
Department of Polyclinic Therapy
Perm
AuthorID: 1004108; Tel.: +7-982-452-76-79
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Review
For citations:
Goryacheva O.G. Diastolic dysfunction of the left ventricle in HIV-infected patients, clinical and prognostic relationships. International journal of Innovative Medicine. 2024;(1):10-16. https://doi.org/10.33667/2782-4101-2024-1-10-16
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